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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 416-420 doi: 10.1007/s11684-012-0224-4
Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acute lymphoblastic leukemia (B-ALL). In children, T-ALL usually has a worse prognosis than B-ALL, although childhood T-ALL prognoses have improved remarkably. The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance. Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor, which confers a much poorer prognosis than any other form of T-ALL. This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL). Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr. Campana’s protocol. Among total 89 T-ALL cases, 74 cases had enough immunophenotype data available to differentiate between ETP (CD1a-, CD8-, CD5dim, at least one marker of stem cell or myeloid lineage) and non-ETP. From these 74 subjects, 12 ETP-ALL cases (16.2%) were identified. The event-free survival (EFS) rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL (P=0.003). The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL (P=0.002). Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis.
关键词: acute lymphoblastic leukemia early T precursor prognosis
A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications
Xiaolin Fan, Yanzhen Xiong, Yuan Wang
《医学前沿(英文)》 2019年 第13卷 第5期 页码 531-539 doi: 10.1007/s11684-019-0700-1
关键词: glioblastoma cell(s) of origin neural stem cells oligodendrocyte precursor cells subventricular zone early diagnosis
Orthopedic management in the polytrauma patient
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 234-242 doi: 10.1007/s11684-012-0218-2
The past century has seen many changes in the management of the polytraumatized orthopedic patient. Early recommendations for non-operative treatment have evolved into early total care (ETC) and damage control orthopedic (DCO) treatment principles. These principles force the treating orthopaedist to take into account multiple patient parameters including hypothermia, coagulopathy and volume status before deciding upon the operative plan. This requires a multidisciplinary approach involving critical care physicians, anesthesiologists and others.
吴伟巍,Patrick T. I. LAM,李启明,Michael C. H. YAM,David A. S. CHEW
《中国工程科学》 2010年 第12卷 第3期 页码 68-72
对国内外建筑业施工现场安全风险的研究进行了文献综述,针对目前研究的不足之处,提出了施工现场安全危险源实时监控和安全风险实时预测的示意性模型,并详细解释了该模型的含义和方法。研究将提供一种基于前馈信号的施工现场安全危险源实时监控和安全风险实时预测的方法;并通过将现有研究的视角引入到施工现场关键安全危险源的前馈信号上,为进一步的研究打下良好的理论基础。
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 437-442 doi: 10.1007/s11684-009-0074-x
关键词: natriuretic peptide precursor A coronary heart disease gene polymorphism allelic discrimination polymorphism single nucleotide
Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical
Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang
《化学科学与工程前沿(英文)》 2021年 第15卷 第1期 页码 148-155 doi: 10.1007/s11705-020-2022-x
关键词: lithium titanate carbon-coated carbon precursor synthetic process
Shilin DENG MD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 323-329 doi: 10.1007/s11684-009-0061-2
关键词: early postmenopausal women bone mineral density exercise effects
RESEARCH AND APPLICATION OF CROP PEST MONITORING AND EARLY WARNING TECHNOLOGY IN CHINA
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 页码 19-36 doi: 10.15302/J-FASE-2021411
The importance of food security, especially in combating the problem of acute hunger, has been underscored as a key component of sustainable development. Considering the major challenge of rapidly increasing demands for both food security and safety, the management and control of major pests is urged to secure supplies of major agricultural products. However, owing to global climate change, biological invasion (e.g., fall armyworm), decreasing agricultural biodiversity, and other factors, a wide range of crop pest outbreaks are becoming more frequent and serious, making China, one of the world’s largest country in terms of agricultural production, one of the primary victims of crop yield loss and the largest pesticide consumer in the world. Nevertheless, the use of science and technology in monitoring and early warning of major crop pests provides better pest management and acts as a fundamental part of an integrated plant protection strategy to achieve the goal of sustainable development of agriculture. This review summarizes the most fundamental information on pest monitoring and early warning in China by documenting the developmental history of research and application, Chinese laws and regulations related to plant protection, and the National Monitoring and Early Warning System, with the purpose of presenting the Chinese model as an example of how to promote regional management of crop pests, especially of cross border pests such as fall armyworm and locust, by international cooperation across pest-related countries.
Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion
Geqing XIA, Chaoying WU
《医学前沿(英文)》 2009年 第3卷 第2期 页码 216-219 doi: 10.1007/s11684-009-0028-3
关键词: mifepristone inducible nitric oxide synthase early pregnancy placental immunity
W. Widiyastuti, Adhi Setiawan, Sugeng Winardi, Tantular Nurtono, Heru Setyawan
《化学科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 104-113 doi: 10.1007/s11705-014-1406-1
关键词: droplet hydroxyapatite particle CFD tubular furnace spray pyrolysis
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia
Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen
《医学前沿(英文)》 2021年 第15卷 第3期 页码 347-371 doi: 10.1007/s11684-020-0821-6
关键词: BCP-ALL subtypes translocation aneuploidy sequence mutations
Role of chemerin/CMKLR1 in the maintenance of early pregnancy
Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing
《医学前沿(英文)》 2018年 第12卷 第5期 页码 525-532 doi: 10.1007/s11684-017-0577-9
Chemerin is a cytokine that attracts much attention in the reproductive process. This study aimed to explore the effects of chemerin and its receptor chemokine-like receptor 1 (CMKLR1) on the maintenance of early pregnancy. The expression levels of chemerin and CMKLR1 in the decidua tissues of 20 early normal pregnant women and 20 early spontaneous abortion women were examined by Western blot and real-time polymerase chain reaction analyses. CMKLR1 receptor antagonist (α-NETA) was then intrauterinely injected into normal pregnant mice model to assess its effect on the outcome of pregnancy and the phosphorylation rate of ERK1/2 in decidua tissues. We found that the expression level of chemerin in women who had experienced early spontaneous abortion was lower than in those who had experienced normal early pregnancy (P<0.01); conversely, CMKLR1 expression was higher in the former than in the latter (P<0.01). In a pregnant-mouse model, the embryo resorption rate of α-NETA group was higher than that in the negative control group (61.5% vs. 10.8%) (P<0.001). Compared with the control group, ERK1/2 phosphorylation in decidua tissues decreased in the α-NETA-treated group (P<0.01). These results suggested that the inhibition of the chemerin/CMKLR1 signaling pathway can lead to the abortion of mouse embryos, and that chemerin/CMKLR1 may play an important role in the maintenance of early pregnancy possibly by regulating ERK1/2 phosphorylation.
关键词: chemerin CMKLR1 early abortion
Weak characteristic information extraction from early fault of wind turbine generator gearbox
Xiaoli XU, Xiuli LIU
《机械工程前沿(英文)》 2017年 第12卷 第3期 页码 357-366 doi: 10.1007/s11465-017-0423-4
Given the weak early degradation characteristic information during early fault evolution in gearbox of wind turbine generator, traditional singular value decomposition (SVD)-based denoising may result in loss of useful information. A weak characteristic information extraction based on µ-SVD and local mean decomposition (LMD) is developed to address this problem. The basic principle of the method is as follows: Determine the denoising order based on cumulative contribution rate, perform signal reconstruction, extract and subject the noisy part of signal to LMD and µ-SVD denoising, and obtain denoised signal through superposition. Experimental results show that this method can significantly weaken signal noise, effectively extract the weak characteristic information of early fault, and facilitate the early fault warning and dynamic predictive maintenance.
关键词: wind turbine generator gearbox µ-singular value decomposition local mean decomposition weak characteristic information extraction early fault warning
Early-onset diabetes: an epidemic in China
Jiemin Pan, Weiping Jia
《医学前沿(英文)》 2018年 第12卷 第6期 页码 624-633 doi: 10.1007/s11684-018-0669-1
Although type 2 diabetes is a disease often associated with aging, the global prevalence of early-onset diabetes has been increasing due to man’s sedentary lifestyle, low-physical activity, obesity, and some non-modifiable risk factors. Many studies have found that individuals with early-onset type 2 diabetes were at higher risk of developing vascular complications than those with late-onset diabetes. Individuals with early-onset diabetes are usually unwilling to visit hospital and have more confidence in their health, which results in poor glycemic control and the delayed detection of diabetes-related complications. Few studies have focused on the treatment and prevention of complications in specific population of individuals with early-onset type 2 diabetes. Therefore, focusing on this particular population is critical for the government and academic societies. Screening for T2DM is imminent for young adults with a family history of diabetes, obesity, markers of insulin resistance, or alcohol consumption. More data are definitely required to establish a reasonable risk model to screen for early-onset diabetes.
Biosensor-based assay of exosome biomarker for early diagnosis of cancer
《医学前沿(英文)》 2022年 第16卷 第2期 页码 157-175 doi: 10.1007/s11684-021-0884-z
标题 作者 时间 类型 操作
Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia
null
期刊论文
A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications
Xiaolin Fan, Yanzhen Xiong, Yuan Wang
期刊论文
The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease
Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,
期刊论文
Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical
Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang
期刊论文
Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial
Shilin DENG MD ,
期刊论文
Expression of inducible nitric oxide synthase in trophoblasts and deciduas in early medical abortion
Geqing XIA, Chaoying WU
期刊论文
Particle formation of hydroxyapatite precursor containing two components in a spray pyrolysis process
W. Widiyastuti, Adhi Setiawan, Sugeng Winardi, Tantular Nurtono, Heru Setyawan
期刊论文
Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia
Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen
期刊论文
Role of chemerin/CMKLR1 in the maintenance of early pregnancy
Xuezhou Yang, Junning Yao, Qipeng Wei, Jinhai Ye, Xiaofang Yin, Xiaozhen Quan, Yanli Lan, Hui Xing
期刊论文
Weak characteristic information extraction from early fault of wind turbine generator gearbox
Xiaoli XU, Xiuli LIU
期刊论文